|
|
NUITFRANCE - Bibliothèque - Fiche bibliographique
Bibliothèque
Cette rubrique recense :
- de la documentation sur les différents thèmes de la nuit (vie nocturne, pollution lumineuse, pollution sonore, ...).
- les données informatiques relatives à l'éclairage public digitalisées et mises à dispositions en open data par certaines communes,
Fil d'Ariane : Accueil >> Bibliothèque >> Fiche bibliographique
Permalien : http://www.nuitfrance.fr/?page=donneesdoc&partie=fiche-bibliographique
Quelques tags associés : [ DOCUMENTATION, PUBLICATIONS, LITTÉRATURE, CONNAISSANCES, LITTÉRATURE GRISE, ARTICLES DE PRESSE, ARTICLES SCIENTIFIQUES, TEXTES JURIDIQUES, PLANS ET PROGRAMMES, JURISPRUDENCE, DÉCRETS, THÈSES ]
► Fiche bibliographique
Afficher la fiche pour le document :
Document " Light Contamination During the Dark Phase in Photoperiodically Controlled Animal Rooms: Effect on Tumor Growth and Metabolism in Rats "
Type de document : |
Articles de revue scientifique |
Thème du document : |
Nuit menacée - Lumière artificielle - Impacts métaboliques et physiologiques sur la faune et la flore |
Groupe biologique : |
Mammifères hors humains et chauves-souris |
Auteur(s) : |
DAUCHY R.T.
SAUER L.A.
BLASK D.E.
VAUGHAN G.M.
|
Date de publication : |
Octobre 1997 |
Langue : |
English/Anglais |
Nom du périodique : |
Laboratory Animal Science |
Précisions : |
Volume 47. Numéro 5. Pages 511-518 |
Lien contenu/source : |
http://www.ncbi.nlm.nih.gov/pubmed/9355094 |
Citation courte : |
Dauchy et al. (1997) |
Citation complète (format NuitFrance) : |
DAUCHY R.T., SAUER L.A., BLASK D.E. & VAUGHAN G.M. (1997). Light Contamination During the Dark Phase in Photoperiodically Controlled Animal Rooms: Effect on Tumor Growth and Metabolism in Rats. Laboratory Animal Science. Volume 47. Numéro 5. Pages 511-518. |
Résumé du document : |
|
Enhanced neoplastic growth and metabolism have been reported in animals maintained in a constant light (24L:0D) environment. Results from this laboratory indicate that tumor growth is directly dependent upon increased ambient blood concentrations of arachidonic and linoleic acids, particularly linoleic acid. Tumor linoleic acid utilization and production if its putative mitogenic metabolite, 13hydroxyoctadecadienoic acid (13-HODE), are suppressed by the circadian neurohormone melatonin, the production of which is itself regulated by light in all mammals. This study was performed to determine whether minimal light contamination (0.2 lux) in an animal room during an otherwise normal dark phase may disrupt normal circadian production of melatonin and affect tumor growth and metabolism. Animals of groups I (12L:12D), II (12L:12-h light-contaminated dark phase), and III (24L:0D) had plasma total fatty acid (TFA), linoleic acid (LA), and melatonin concentrations measured prior to tumor implantation; groups I and II had daily cycles in plasma TFA and LA values, whereas group III had constant values throughout the day. The integrated mean TFA and LA values for the entire day were similar in all groups. Although group-I animals had a normal nocturnal surge of melatonin (127.0 pg/ml) at 2400 h, the nocturnal amplitude was suppressed in group-II animals (16.0 pg/ml); circadian variation in melatonin concentration was not seen in group-III animals (7.4 pg/ml). At 12 weeks of age, rats had the Morris hepatoma 7288CTC implanted as “tissue-isolated” tumors grown subcutaneously. Latency to onset of palpable tumor mass for groups I, II, and III was 11, 9, and 5 days respectively. Tumor growth rates were 0.72 ± 0.09, 1.30 ± 0.15, and 1.48 ± 0.17 g/d (mean ± SD, n = 6/group) in groups I, II, and III respectively. Arteriovenous difference measurements for TFA and LA across the tumors were 4.22 ± 0.89 and 0.83 ± 0.18 (group I), 8.26 ± 0.66 and 1.64 ± 0.13 (group II), and 7.10 ± 0.78 and 1.50 ± 0.16 (group III) /min/g, and groups II and III were significantly different from group I (P < 0.05). Tumor TFA and LA contents were 14.3 ± 1.7 and 1.8 ± 0.3 (group I), 52.9 ± 5.5 and 7.9 ± 0.8 (group II), and 106.0 ± 12.0 and 18.5 ± 2.4 (group III) g/g and were significantly different from each other (P < 0.001). Production of 13-HODE by the hepatomas in groups I, II, and III was 35.5 ± 6.3, 109.6 ± 10.6, and 196.2 ± 34.9 ng/min/g respectively, values which also were significantly different among groups (P < 0.001). The results indicate that minimal light contamination of only 0.2 lux during an otherwise normal dark phase inhibits host melatonin secretion and increases the rate of tumor growth and lipid uptake and metabolism. These data suggest that great care must be taken to prevent “light-leaks” in animal rooms during the dark phase of a diurnal cycle because such contamination may adversely affect the outcome of tumor growth investigations.
|
Saisie sur NuitFrance par : |
Rosor |
Saisie sur NuitFrance en : |
Septembre 2014 |
Identifiant NuitFrance : |
NF-BIBLI-514 |
Permalien de la fiche NuitFrance : |
http://www.nuitfrance.fr/?page=donneesdoc&partie=fiche-bibliographique&id_doc=514 |
|
|
